Cancer genome and Immune system regulation
Our lab focuses on studying gene regulation in viral associated cancers (e.g. EBV and HBV related tumors), autoimmune disorders (e.g. Rheumatoid Arthritis) , and infectious diseases (e.g. COVID-19). We utilize biological assays and computational models to identify novel biological pathways, new host-pathogen interactions and regulatory RNAs (e.g. enhancer RNAs and circular RNAs) that could trigger disease.
We are exploiting single cell and bulkhigh throughput sequencing data (e.g. RNA-seq, ChIP-seq, ATAC-seq, Hi-C) using machine learning tools to guide experiments.
Select recent papers
2018- Nature Immunology